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Grapefruit seed extract (GSE) is a natural compound derived from the seed and pulp of grapefruit. It has very high amounts of disease-fighting, free-radical eliminating antioxidants and phytonutrients called bioflavonoids. One of these powerful bioflavanoids (plant antioxidants) include the chemical component hesperidin, a well-known natural immune-system stimulator and booster.